| CAMPEONATO DE APERTURA 2021 | ||||
| 1º Fecha | ||||
| 5-feb-2021 | Luque | Sportivo Luqueño | 3 | Borja (2, 1P), Dure |
| Guaireña | 1 | Mendoza | ||
| 5-feb-2021 | Asuncion | Guarani | 2 | Florentin, Servio (P) |
| Nacional | 2 | Fleitas, Villagra | ||
| 6-feb-2021 | Itaugua | 12 de Octubre | 2 | Velazquez (P), Da Silva |
| River Plate | 2 | Zeballos (P), Miño | ||
| 6-feb-2021 | Asuncion | Sol de America | 1 | Cazal |
| Cerro Porteño | 3 | Gimenez, Morales, Aquino | ||
| 7-feb-2021 | Asuncion | Olimpia | 0 | |
| Libertad | 1 | Cardozo (P) | ||
| 2º Fecha | ||||
| 9-feb-2021 | Asuncion | River Plate | 1 | Godoy |
| Guarani | 4 | Florentin, Fernandez (2), Valdez | ||
| 9-feb-2021 | Asuncion | Nacional | 1 | Fleitas |
| Sol de America | 0 | |||
| 10-feb-2021 | Asuncion | Cerro Porteño | 1 | Boselli |
| Sportivo Luqueño | 0 | |||
| 10-feb-2021 | Itaugua | 12 de Octubre | 0 | |
| Olimpia | 2 | Paiva (P), Torres (P) | ||
| 24-feb-2021 | Asuncion | Guaireña | 1 | Mendoza |
| Libertad | 0 | |||
| 3º Fecha | ||||
| 13-feb-2021 | Asuncion | Guarani | 2 | Florentin, Marin |
| 12 de Octubre | 1 | Nuñez | ||
| 14-feb-2021 | Luque | Sportivo Luqueño | 0 | |
| Nacional | 3 | Villagra (2, 1P), Arrua | ||
| 14-feb-2021 | Asuncion | Olimpia | 0 | |
| Guaireña | 0 | |||
| 15-feb-2021 | Asuncion | Sol de America | 1 | Ferreira |
| River Plate | 1 | Zeballos (P) | ||
| 15-feb-2021 | Asuncion | Libertad | 2 | Baez, Bareiro |
| Cerro Porteño | 1 | Carrizo | ||
| 4º Fecha | ||||
| 19-feb-2021 | Asuncion | River Plate | 1 | Gonzalez |
| Sportivo Luqueño | 0 | |||
| 20-feb-2021 | Itaugua | 12 de Octubre | 0 | |
| Sol de America | 5 | Cazal, Martinez (2), Viera, Leal | ||
| 20-feb-2021 | Asuncion | Guarani | 0 | |
| Olimpia | 3 | Santa Cruz, Ojeda, Sosa | ||
| 21-feb-2021 | Asuncion | Cerro Porteño | 2 | Aquino, Boselli |
| Guaireña | 2 | Romero, Duarte | ||
| 21-feb-2021 | Asuncion | Nacional | 0 | |
| Libertad | 3 | Enciso, Delvalle, Cardozo | ||
| 5º Fecha | ||||
| 26-feb-2021 | Luque | Sportivo Luqueño | 1 | Gonzalez |
| 12 de Octubre | 0 | |||
| 27-feb-2021 | Asuncion | Sol de America | 1 | Leal |
| Guarani | 3 | Mana (P), Marin, Fernandez | ||
| 28-feb-2021 | Asuncion | Olimpia | 2 | Sosa, Recalde |
| Cerro Porteño | 0 | |||
| 1-mar-2021 | Villarrica | Guaireña | 1 | Alborno |
| Nacional | 0 | |||
| 1-mar-2021 | Asuncion | Libertad | 2 | Cardozo (P), Barboza |
| River Plate | 1 | Contrera | ||
| 6º Fecha | ||||
| 5-mar-2021 | Asuncion | River Plate | 0 | |
| Guaireña | 1 | Brizuela | ||
| 5-mar-2021 | Itaugua | 12 de Octubre | 2 | Ojeda, Velazquez |
| Libertad | 1 | Baez | ||
| 6-mar-2021 | Asuncion | Nacional | 2 | Villagra, Zaracho |
| Cerro Porteño | 0 | |||
| 6-mar-2021 | Asuncion | Sol de America | 0 | |
| Olimpia | 2 | Santa Cruz, Recalde | ||
| 7-mar-2021 | Asuncion | Guarani | 0 | |
| Sportivo Luqueño | 1 | Cabral | ||
| 7º Fecha | ||||
| 9-mar-2021 | Villarica | River Plate | 0 | |
| 12 de Octubre | 0 | |||
| 9-mar-2021 | Asuncion | Cerro Porteño | 3 | Boselli (2), Vera |
| River Plate | 0 | |||
| 10-mar-2021 | Asuncion | Olimpia | 1 | Silva (P) |
| Nacional | 4 | Villagra, Arrua, Zaracho, Gaona Lugo | ||
| 10-mar-2021 | Luque | Sportivo Luqueño | 0 | |
| Sol de America | 0 | |||
| 27-mar-2021 | Asuncion | Libertad | 1 | Cardozo |
| Guarani | 1 | Villalva | ||
| 8º Fecha | ||||
| 13-mar-2021 | Itaugua | 12 de Octubre | 0 | |
| Cerro Porteño | 2 | Morales (2) | ||
| 13-mar-2021 | Asuncion | River Plate | 0 | |
| Nacional | 0 | |||
| 13-mar-2021 | Asuncion | Sol de America | 0 | |
| Libertad | 2 | Bocanegra, Cardozo | ||
| 14-mar-2021 | Asuncion | Guarani | 0 | |
| Guaireña | 3 | Candia (P), Romero, Verdun | ||
| 14-mar-2021 | Luque | Sportivo Luqueño | 4 | Beltran, Benitez (2), Martinez |
| Olimpia | 2 | Ortiz, Recalde | ||
| 9º Fecha | ||||
| 20-mar-2021 | Asuncion | Nacional | 1 | Villagra |
| 12 de Octubre | 1 | Nuñez | ||
| 21-mar-2021 | Asuncion | Cerro Porteño | 2 | Aquino, Morales |
| Guarani | 1 | Benitez | ||
| 21-mar-2021 | Asuncion | Olimpia | 5 | Recalde (2), Silva, Gonzalez, Rojas |
| River Plate | 1 | Zeballos | ||
| 22-mar-2021 | Villarrica | Guaireña | 2 | Romero (2) |
| Sol de America | 2 | Viera, Ortiz | ||
| 22-mar-2021 | Asuncion | Libertad | 2 | Merlini (2) |
| Sportivo Luqueño | 0 | |||
| 10º Fecha | ||||
| 1-abr-2021 | Asuncion | River Plate | 0 | |
| 12 de Octubre | 2 | Velazquez, Salinas | ||
| 1-abr-2021 | Asuncion | Nacional | 2 | Villagra (P), Arrua |
| Guarani | 0 | |||
| 3-abr-2021 | Villarrica | Guaireña | 3 | Paniagua (2), Romero |
| Sportivo Luqueño | 0 | |||
| 3-abr-2021 | Asuncion | Libertad | 0 | |
| Olimpia | 1 | Recalde | ||
| 4-abr-2021 | Asuncion | Cerro Porteño | 1 | Morales |
| Sol de America | 0 | |||
| 11º Fecha | ||||
| 10-abr-2021 | Asuncion | Sol de America | 1 | Villagra |
| Nacional | 2 | Gaona Lugo, Murillo | ||
| 10-abr-2021 | Asuncion | Olimpia | 2 | Recalde, Torres |
| 12 de Octubre | 2 | Rios, Aguilar (P) | ||
| 11-abr-2021 | Luque | Sportivo Luqueño | 3 | Cabral (2), Dure |
| Cerro Porteño | 3 | Morales, Arzamendia, Boselli | ||
| 11-abr-2021 | Asuncion | Libertad | 2 | Villalba, Enciso |
| Guaireña | 1 | Parra | ||
| 12-abr-2021 | Asuncion | Guarani | 2 | Fernandez, Servio (P) |
| River Plate | 0 | |||
| 12º Fecha | ||||
| 16-abr-2021 | Villarrica | Guaireña | 1 | Caceres |
| Olimpia | 2 | Silva (2) | ||
| 16-abr-2021 | Itaugua | 12 de Octubre | 1 | Nuñez |
| Guarani | 1 | Colman | ||
| 17-abr-2021 | Asuncion | Nacional | 1 | Villagra (P) |
| Sportivo Luqueño | 0 | |||
| 17-abr-2021 | Asuncion | River Plate | 0 | |
| Sol de America | 2 | Ortigoza (P), Ubeda | ||
| 18-abr-2021 | Asuncion | Cerro Porteño | 0 | |
| Libertad | 3 | Villalba, Bareiro, Enciso | ||
| 13º Fecha | ||||
| 23-abr-2021 | Asuncion | Sol de America | 0 | |
| 12 de Octubre | 3 | Caceres, Velasquez (P), Salinas | ||
| 24-abr-2021 | Asuncion | Olimpia | 2 | Ortiz, Gonzalez |
| Guarani | 1 | Fernandez | ||
| 25-abr-2021 | Villarrica | Guaireña | 0 | |
| Cerro Porteño | 1 | Arzamendia | ||
| 25-abr-2021 | Asuncion | Libertad | 1 | Cardozo |
| Nacional | 1 | Arrua | ||
| 26-abr-2021 | Luque | Sportivo Luqueño | 2 | Villalba, Beltran |
| River Plate | 2 | Perez, Zeballos (P) | ||
| 14º Fecha | ||||
| 30-abr-2021 | Asuncion | Nacional | 1 | Fleitas |
| Guaireña | 3 | Parra, Caceres, Brizuela | ||
| 30-abr-2012 | Itaugua | 12 de Octubre | 1 | Caceres |
| Sportivo Luqueño | 0 | |||
| 1-may-2021 | Asuncion | Cerro Porteño | 2 | Boselli, Patiño |
| Olimpia | 0 | |||
| 2-may-2021 | Asuncion | Guarani | 2 | Fernandez, Valdez |
| Sol de America | 0 | |||
| 3-may-2021 | Asuncion | River Plate | 1 | Gonzalez |
| Libertad | 3 | Cougo, Cardozo, Bareiro | ||
| 15º Fecha | ||||
| 8-may-2021 | Luque | Sportivo Luqueño | 1 | Borja (P) |
| Guarani | 2 | Servio (P), Valdez | ||
| 8-may-2021 | Asuncion | Cerro Porteño | 2 | Boselli, Morales |
| Nacional | 2 | Arrua, Ayala | ||
| 9-may-2021 | Asuncion | Olimpia | 3 | W. Gonzalez, Silva (P), D. Gonzalez (P) |
| Sol de America | 3 | Leal, Salcedo (A), Valdez (P) | ||
| 9-may-2021 | Asuncion | Libertad | 3 | Merlini, Baez, Martinez |
| 12 de Octubre | 1 | Marabel | ||
| 9-may-2021 | Villarrica | Guaireña | 0 | |
| River Plate | 0 | |||
| 16º Fecha | ||||
| 15-may-2021 | Asuncion | Sol de America | 0 | |
| Sportivo Luqueño | 2 | Benitez, Vera | ||
| 15-may-2021 | Itaugua | 12 de Octubre | 1 | Velazquez |
| Guaireña | 1 | Nuñez | ||
| 16-may-2021 | Asuncion | River Plate | 1 | Otazu |
| Cerro Porteño | 1 | Martinez (P) | ||
| 16-may-2021 | Asuncion | Guarani | 1 | Servio (P) |
| Libertad | 6 | Cardozo (2), Villalba (2), Martinez, Enciso | ||
| 17-may-2021 | Asuncion | Nacional | 2 | Villagra (P), Arrua |
| Olimpia | 1 | Camacho | ||
| 17º Fecha | ||||
| 21-may-2021 | Villarrica | Guaireña | 0 | |
| Guarani | 0 | |||
| 22-may-2021 | Asuncion | Libertad | 1 | Baez |
| Sol de America | 2 | Leal, Valdez (P) | ||
| 23-may-2021 | Asuncion | Cerro Porteño | 0 | |
| 12 de Octubre | 1 | Nuñez | ||
| 23-may-2021 | Asuncion | Olimpia | 4 | Camacho, Silva (P), Gonzalez, Pitta (P) |
| Sportivo Luqueño | 1 | Benitez | ||
| 23-may-2021 | Asuncion | Nacional | 0 | |
| River Plate | 1 | Perez | ||
| 18º Fecha | ||||
| 28-may-2021 | Asuncion | Sol de America | 0 | |
| Guaireña | 0 | |||
| 28-may-2021 | Asuncion | Guarani | 2 | Pereira, Florentin |
| Cerro Porteño | 0 | |||
| 29-may-2021 | Luque | Sportivo Luqueño | 1 | Ortiz |
| Libertad | 3 | Martinez, Bogarin, Ferreira | ||
| 30-may-2021 | Asuncion | River Plate | 1 | Zeballos (P) |
| Olimpia | 2 | Pitta, Candia | ||
| 30-may-2021 | Itaugua | 12 de Octubre | 2 | Barrios, Nuñez |
| Nacional | 2 | Riveros, Villagra | ||